Solutions & R&D services
Human organoid R&D services
Connect target validation, candidate evaluation, tumor–immune response and safety studies with models, assays and reports selected for your indication, modality and available samples.
Discovery research
Discovery & validation
Test whether genetic or pharmacologic target perturbation produces the expected phenotype and pathway changes in a relevant human organoid model.
01Target validation & mechanism studies
Determine how target modulation changes disease-relevant phenotypes, molecular pathways and treatment response in human organoid models.
↗
Mouse intestinal organoid · barrier methods02Mechanism & biomarkers
Relate tissue, functional and molecular changes to the observed phenotype and identify response-associated biomarker candidates for further validation.
↗
03Custom model development
Develop a model and assay plan for specialized tissues, rare diseases or complex co-cultures, starting from the samples and endpoints available to your program.
↗Candidate studies
Candidate evaluation
Compare single agents, dose responses and combinations with modality-relevant efficacy, immune and mechanism readouts.
01Organoid efficacy screening
Compare single agents, dose responses and combinations in selected organoid models to identify dose-dependent and model-specific candidate responses.
↗
02Immuno-oncology
Evaluate immune activation and tumor-cell killing in PDO 2.0 / ALI models or immune co-cultures, with tissue imaging and functional assays tailored to your candidate.
↗
PDAC PDO 2.0 · CK19 and CD3 tissue profiling03Antibody, multispecific & T-cell engager (TCE) studies
Evaluate antibody, multispecific and T-cell engager (TCE) candidates using target profiling, defined effector-to-target ratios, live-cell or endpoint cytotoxicity and cytokine readouts.
↗
04ADC research
Combine target expression, spatial distribution, cytotoxicity and bystander-effect readouts in an organoid study matched to the candidate ADC.
↗Safety & drug delivery
Safety & drug delivery
Assess organ injury and exposure-dependent response windows, then develop barrier-permeability or candidate-transport assays for the relevant tissue system.
01Safety & toxicology
Focus on one priority organ with an injury assessment tailored to the model and candidate, then compare dose and exposure time and investigate the mechanism of tissue damage.
↗
Normal lung · LPS injury
Human kidney organoid · cisplatin response02Multi-organ safety in human organoids
Compare normal kidney, lung and GI organoids with adjacent non-tumor liver or other relevant models in a coordinated exposure design to rank organ risks and focus follow-up safety studies.
↗
Mouse intestinal organoid · barrier methods03Drug delivery & barrier permeability
Assess barrier integrity, injury and repair, then develop permeability or candidate-transport assays for the relevant tissue system.
↗Tell us about your candidate, sample context and program priorities; our scientists will recommend the model, assay panel and study plan.