ATII and SCGB1A1/KRT5 profiling, serial morphology, and AT1/AT2 changes after LPS exposure together guide pulmonary-injury model selection, observation timing and endpoint design.
STUDY EVIDENCE
ATII, SCGB1A1 (CC10) and KRT5 profiling establishes the alveolar and airway context. Serial morphology and AT1/AT2 readouts under LPS conditions help define observation windows and endpoints for pulmonary-injury studies.
Bright-field, DAPI, LysoTracker and merged views show alveolar organoid structure and ATII-associated acidic-organelle signal.
Supports selection of alveolar-associated phenotype and injury endpoints
Immunofluorescence adds club-cell and basal-cell profiling to distinguish airway- and alveolar-focused questions.
Supports selection of airway-focused assays
Serial bright-field views guide post-treatment timing and the transition into quantitative assays.
Supports selection of the injury-study window and sampling points
Bright-field, AT1, AT2, DAPI and merged views provide alveolar-cell context under the injury condition.
Supports interpretation of morphology alongside alveolar-cell endpointsThe normal-lung organoid study covers model identity, serial morphology and alveolar readouts under LPS conditions. Candidate safety studies can add program-specific dosing and exposure conditions, appropriate controls and replication, and organ-specific quantitative endpoints.
Related models and services
PROJECT DISCUSSION
Tell us which model features and readouts matter most. Our scientists will recommend the model, QC plan and study endpoints.
ATII and SCGB1A1/KRT5 profiling, serial morphology, and AT1/AT2 changes after LPS exposure together guide pulmonary-injury model selection, observation timing and endpoint design.
STUDY EVIDENCE
ATII, SCGB1A1 (CC10) and KRT5 profiling establishes the alveolar and airway context. Serial morphology and AT1/AT2 readouts under LPS conditions help define observation windows and endpoints for pulmonary-injury studies.
Bright-field, DAPI, LysoTracker and merged views show alveolar organoid structure and ATII-associated acidic-organelle signal.
Supports selection of alveolar-associated phenotype and injury endpointsImmunofluorescence adds club-cell and basal-cell profiling to distinguish airway- and alveolar-focused questions.
Supports selection of airway-focused assaysSerial bright-field views guide post-treatment timing and the transition into quantitative assays.
Supports selection of the injury-study window and sampling pointsBright-field, AT1, AT2, DAPI and merged views provide alveolar-cell context under the injury condition.
Supports interpretation of morphology alongside alveolar-cell endpointsThe normal-lung organoid study covers model identity, serial morphology and alveolar readouts under LPS conditions. Candidate safety studies can add program-specific dosing and exposure conditions, appropriate controls and replication, and organ-specific quantitative endpoints.
Related models and services
PROJECT DISCUSSION
Tell us which model features and readouts matter most. Our scientists will recommend the model, QC plan and study endpoints.
