Normal gastric organoids: culture & histology
P0–P2 culture, H&E, Ki67 and mucin-associated immunofluorescence show growth across passages and epithelial features.
CULTURE, HISTOLOGY & PHENOTYPE
Growth and secretory phenotype
Bright-field imaging and H&E show normal gastric organoid growth and epithelial structure, while Ki67 and mucin-associated immunofluorescence add proliferative and secretory phenotypes.
View imageCulture morphology: a bright-field image shows normal gastric organoid growth in 3D culture.
Model & assay data
View imageHistology: H&E is used to evaluate epithelial organization and lumen-like structure.
Model & assay data
View imageImmunofluorescence: Ki67 and mucin-associated signals add proliferation and secretory context.
Model & assay data
View imageAdditional field: proliferation and mucin signals across organoid structures are interpreted with culture, passaging and histology results to assess model status.
Model & assay dataCulture and serial passaging
Serial imaging follows normal gastric organoids from P0 through P2, showing growth and morphology across passages.
Histology and epithelial features
H&E describes tissue architecture, while Ki67 and mucin-associated immunofluorescence add proliferation and secretory context.
- P0–P2 bright-field imaging
- H&E
- Ki67
- Mucin-associated immunofluorescence
Potential study use
Use the model to study gastric epithelial biology, drug exposure and tissue injury with endpoints defined for the program.
Configure gastric epithelial and injury studies
Culture morphology, histology and epithelial features provide the starting point. Batch context, exposure conditions and additional readouts can then be selected for the study objective.
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PROJECT DISCUSSION
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